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Well from the get go, I think Google Mobile and Domain's differences only lies in the platform onto which the advertisement will be served.
For mobile, the ads will obviously be served on webpage optimized for mobile devices and for domain, it must be for the actual websites made for desktop/laptop display.
Mobile ads also works very well on Games and Applications on mobile devices since I for one am seeing some (annoying) ads on games like Angry Birds, Inotia, etc.
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